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. 2024 May 20;14(23):16218–16227. doi: 10.1039/d4ra01765j

Antibacterial activity of the target compounds against the test bacteria at concentrations of 100 and 50 μg mL−1a.

Compounds Inhibition rate (%)
XOO XAC PSA
100 μg mL−1 50 μg mL−1 100 μg mL−1 50 μg mL−1 100 μg mL−1 50 μg mL−1
6a 18.93 ± 2.63 9.18 ± 1.71 34.41 ± 1.56 17.71 ± 3.36 16.53 ± 2.11 7.38 ± 2.20
6b 40.21 ± 3.71 18.54 ± 2.59 13.13 ± 1.34 10.06 ± 0.78 11.24 ± 2.31 8.31 ± 1.12
6c 26.40 ± 3.93 16.81 ± 3.41 79.33 ± 2.54 63.26 ± 1.56 8.49 ± 4.95 5.50 ± 4.30
6d 14.88 ± 4.36 0 48.34 ± 2.87 43.56 ± 3.80 9.39 ± 1.49 0
6e 22.04 ± 2.65 4.84 ± 2.04 58.89 ± 2.73 40.81 ± 2.16 12.10 ± 2.13 0
6f 6.38 ± 1.25 1.47 ± 1.71 41.58 ± 3.88 20.16 ± 1.35 15.95 ± 3.49 7.91 ± 1.71
6g 17.89 ± 3.43 8.49 ± 2.70 40.46 ± 1.25 26.64 ± 4.15 19.88 ± 1.94 11.05 ± 5.93
6h 47.89 ± 0.53 46.16 ± 4.69 71.93 ± 3.26 33.32 ± 3.03 39.28 ± 0.66 8.70 ± 2.91
6i 38.40 ± 2.05 17.98 ± 1.21 45.84 ± 3.28 22.13 ± 1.35 21.05 ± 2.49 10.83 ± 1.91
6j 16.03 ± 2.72 1.60 ± 0.19 14.45 ± 4.05 10.59 ± 1.63 23.10 ± 3.44 0
6k 54.27 ± 3.52 29.31 ± 1.11 18.46 ± 1.28 10.54 ± 0.95 28.94 ± 1.59 19.32 ± 1.71
6l 56.43 ± 0.65 30.25 ± 0.81 40.58 ± 2.28 20.06 ± 1.35 45.73 ± 3.47 19.85 ± 0.97
6m 36.64 ± 2.57 13.95 ± 4.42 51.85 ± 2.81 42.63 ± 3.03 36.34 ± 3.24 0
6n 30.66 ± 3.01 11.95 ± 4.47 68.91 ± 0.27 50.46 ± 1.31 35.89 ± 3.79 0
6o 15.48 ± 1.35 7.14 ± 3.41 52.99 ± 1.28 35.53 ± 1.38 17.08 ± 5.49 8.81 ± 1.15
6p 37.46 ± 1.07 10.34 ± 3.41 85.76 ± 0.09 57.85 ± 2.41 28.59 ± 1.43 0
6q 11.38 ± 0.35 7.73 ± 0.61 58.15 ± 2.18 34.73 ± 2.31 54.17 ± 3.49 24.91 ± 1.08
6r 5.60 ± 1.75 0.85 ± 1.91 41.38 ± 1.28 22.13 ± 1.37 23.58 ± 1.09 10.16 ± 3.11
6s 35.86 ± 1.25 17.34 ± 0.81 55.35 ± 1.18 36.13 ± 0.35 39.84 ± 2.38 19.91 ± 1.01
6t 40.28 ± 3.10 19.18 ± 0.92 46.22 ± 1.71 42.77 ± 1.90 35.32 ± 3.91 5.05 ± 1.16
6u 19.00 ± 4.35 13.73 ± 6.91 39.01 ± 8.98 37.03 ± 2.35 19.18 ± 5.49 4.41 ± 1.71
6v 24.50 ± 1.04 19.72 ± 6.78 58.31 ± 1.72 43.93 ± 3.44 29.59 ± 1.32 10.61 ± 1.55
6w 31.16 ± 0.33 15.63 ± 1.39 56.58 ± 1.26 32.55 ± 0.93 44.21 ± 1.56 20.22 ± 1.74
6x 44.38 ± 1.23 31.09 ± 2.17 18.33 ± 1.06 11.54 ± 1.03 45.38 ± 2.06 22.56 ± 1.21
Thiadiazole copper 61.36 ± 3.17 50.36 ± 3.72 76.59 ± 3.10 48.01 ± 2.33 92.67 ± 5.22 45.29 ± 3.25
a

Average of three replicates.