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Cases 5 and 6 (novel substitution mutations) (A) Timeline of Case 5. (B) Timeline of Case 6. *whole brain radiotherapy. CDKN2A, cyclin-dependent kinase inhibitor 2A; EGFR, epidermal growth factor receptor; NGS, next-generation sequencing; NSCLC, non-small cell lung cancer; PD, progressive disease; PR, partial response; QD, each day; RT, radiotherapy; SD, stable disease; TP53, tumor protein 53.
