Table 4.

Challenges to Treatment and opportunities for optimizing antifungal treatment.

Challenges	Opportunities for improvement
Lack of diagnostic capacity and late diagnosis [50]	Diagnostic capacity building for early diagnosis [50]
Affordable prices[50,66]	Access to generic drugs[67,68]
Local antifungal availability under normal circumstances and if stock-outs [50,65]	- Raising awareness [50]
Treatment adherence to comorbidity treatments (i.e., HIV/AIDS) [69,70] Antifungal resistances: acquired and intrinsic [50]	- Enhanced Access to therapeutic drug monitoring to address drug-drug interactions
Antifungal susceptibility testing	- Antifungal stewardship to address emerging antifungal resistance
Drug-drug interactions and drug-related adverse effects (use ART and anti-TBs [50,71]

Abbreviations: ART-anti-retroviral therapy, TB, tuberculosis.