Table 1.
Sociodemographic and clinical characteristics of participants from TODAY and SEARCH for Diabetes in Youth (SEARCH 4 cohort visit) who underwent screening and adjudication of diabetes related medical events.
| SEARCH T1D N=564 | SEARCH T2D N=149 | TODAY T2D N=495 | |
|---|---|---|---|
|
| |||
| Age at diabetes onset (years), mean(sd) | 9.7 (4.4) | 14.3 (2.7) | 13.2 (2.1)* |
|
| |||
| Age at last visit (years), mean(sd) | 21.1 (5.2) | 24.3 (4.4) | 26.5 (2.7) |
|
| |||
| Duration of Diabetes (years), mean(sd) | 11.4 (3.7) | 10.0 (3.8) | 13.3 (1.8)* |
|
| |||
| Female Sex, N(%) | 305 (54.1%) | 98 (65.8%) | 324 (65.5%) |
|
| |||
| Race/Ethnicity, N(%) | * | ||
|
| |||
| Non-Hispanic White | 334 (59.2%) | 23 (15.4%) | 94 (19.0%) |
|
| |||
| Black | 98 (17.4%) | 74 (49.7%) | 174 (35.2%) |
|
| |||
| Hispanic | 107 (19.0%) | 40 (26.8%) | 188 (38.0%) |
|
| |||
| Other | 25 (4.4%) | 12 (8.1%) | 39 (7.9%) |
|
| |||
| Insurance, N(%) | |||
|
| |||
| Private | 399 (70.7%) | 54 (36.2%) | 163 (32.9%) |
|
| |||
| Medicaid/Public | 106 (18.8%) | 53 (35.6%) | 207 (41.8%) |
|
| |||
| None | 17 (3.0%) | 23 (15.4%) | 61 (12.3%) |
|
| |||
| Other | 34 (6.0%) | 13 (8.7%) | 31 (6.3%) |
|
| |||
| Unknown | 8 (1.4%) | 6 (4.0%) | 33 (6.7%) |
|
| |||
| Household Income, N(%) | * | ||
|
| |||
| <$25K | 82 (14.5%) | 43 (28.9%) | 299 (60.4%) |
|
| |||
| $25–49K | 102 (18.1%) | 27 (18.1%) | 139 (28.1%) |
|
| |||
| $50–74K | 65 (11.5%) | 6 (4.0%) | 35 (7.1%) |
|
| |||
| $75K+ | 168 (29.8%) | 5 (3.4%) | 5 (1.0%) |
|
| |||
| DK/Ref | 147 (26.1%) | 68 (45.6%) | 17 (3.4%) |
|
| |||
| Participant Education, N(%) | * | ||
|
| |||
| Less than HS gr | 194 (34.6%) | 27 (18.4%) | 60 (12.1%) |
|
| |||
| HS graduate | 122 (21.7%) | 56 (38.1%) | 311 (62.8%) |
|
| |||
| Some College/Associates Degree | 169 (30.1%) | 54 (36.7%) | 49 (9.9%) |
|
| |||
| Bachelor degree or higher | 76 (13.5%) | 10 (6.8%) | 75 (15.2%) |
|
| |||
| Unknown | 3 | 2 | 0 |
|
| |||
| Medication Regimen, N(%) | * | ||
|
| |||
| Metformin only | 1 (0.2%) | 11 (7.9%) | 92 (18.6%) |
|
| |||
| Insulin only | 540 (95.7%) | 47 (33.8%) | 107 (21.6%) |
|
| |||
| Insulin + Something else | 19 (3.4%) | 38 (27.3%) | 154 (31.1%) |
|
| |||
| Other Oral | 1 (0.2%) | 7 (5.0%) | 23 (4.6%) |
|
| |||
| None | 3 (0.5%) | 36 (25.9%) | 119 (24.0%) |
|
| |||
| Unknown | 0 | 10 | 0 |
|
| |||
| HbA1c (%), mean(sd) | 9.1 (2.2) | 9.5 (2.9) | 9.4 (2.8) |
| Mmol/mol, mean(sd) | 76 (24) | 80 (32) | 79 (31) |
|
| |||
| Body Mass Index (kg/m2), mean(sd) | 25.6 (5.4) | 36.4 (9.3) | 36.0 (8.4) |
|
| |||
| < 25 | 302 (53.5%) | 11 (7.4%) | 25 (5.3%) |
|
| |||
| 25–30 | 161 (28.5%) | 23 (15.4%) | 85 (17.9%) |
|
| |||
| 30–40 | 90 (16.0%) | 73 (49.0%) | 235 (49.6%) |
|
| |||
| 40 + | 11 (2.0%) | 42 (28.2%) | 129 (27.2%) |
|
| |||
| Systolic Blood Pressure, mean(sd) | 110.1 (11.7) | 123.5 (18.8) | 122.3 (14.9) |
|
| |||
| Diastolic Blood Pressure, mean(sd) | 70.7 (9.2) | 79.7 (13.6) | 76.7 (11.2)* |
|
| |||
| Mean Arterial Pressure, mean(sd) | 83.9 (9.0) | 94.3 (14.5) | 91.9 (11.8) |
|
| |||
| LDL (mg/dl), mean(sd) | 105.9 (33.1) | 108.4 (31.6) | 102.7 (33.5) |
|
| |||
| Triglycerides (mg/dl), median (IQR) | 78.0 (59.0; 109.5) | 108.0 (78.0; 171.0) | 115.0 (79.0; 172.0) |
|
| |||
| ACEI/ARB | * | ||
|
| |||
| Yes | 29 (5.4%) | 14 (10.8%) | 146 (29.5%) |
|
| |||
| No | 506 (94.6%) | 116 (89.2%) | 349 (70.5%) |
|
| |||
| Unknown | 29 | 19 | 0 |
|
| |||
| Statin use | * | ||
|
| |||
| Yes | 15 (2.8%) | 8 (6.2%) | 72 (14.5%) |
|
| |||
| No | 520 (97.2%) | 122 (93.8%) | 423 (85.5%) |
|
| |||
| Unknown | 29 | 19 | 0 |
*
p<0.05 comparing SEARCH type 2 and TODAY type 2 (t-test, Kruskal-Wallis, or Chi-square test)