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. 2024 May 12;38:438–454. doi: 10.1016/j.bioactmat.2024.05.015

Fig. 6.

Fig. 6

Systematic evaluation of Feb-1+MSCs+NPs treatment system. (a)Timeline of treatment regimens for rats with spinal cord contusions in the Sham, SCI, Feb-1, Feb-1 + MSCs, Feb-1 + MSCs + NPs groups. (b) BBB scores at 6 consecutive weeks after SCI (n = 7, one-way ANOVA, Tukey's post hoc tests, *P < 0.05, ##P < 0.01, * means the comparison of the Feb-1 + MSCs + NPs and Feb-1 + MSCs group, # means the comparison of the Feb-1 + MSCs + NPs and Feb-1 group). (c) Catwalk step sequence scores at week six after SCI (n = 7, one-way ANOVA, Tukey's post hoc tests, **P < 0.01, and ****P < 0.0001). (d–e) The mean print area of the rat when passing through the trail (n = 7, one-way ANOVA, Tukey's post hoc tests, **P < 0.01, ***P < 0.001, and ****P < 0.0001). (f, i-j) Immunofluorescence staining at week six after SCI. GFAP (red) and NeuN (green); scale bar = 800 μm, high magnification: scale bar = 100 μm. (n = 7, one-way ANOVA, Tukey's post hoc tests, **P < 0.01, ***P < 0.001, and ****P < 0.0001). (g–h) Maximum paw pressure on the ceiling as the rat passes through it (n = 7, one-way ANOVA, Tukey's post hoc tests, *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001). (k) 3D reconstruction of the pressure on rat paws contacting the ceiling.