Figure 8.

Sequence alignment of the E.coli MutT, hMTH1 and hMYH C-terminal regions (amino acids 341–501) and the E.coli MutY C-terminal region (amino acids 211–350). The alignments for MutT, hMYH and MutY are based on the data of Noll et al. (55) and those for hMTH1 and MutT are based on the data of Fujii et al. (45). Residues conserved among more than three proteins are shown in a yellow box and residues conserved only between MutT and hMTH1 or hMYH and MutY are shown in a blue or green box, respectively. Residues conserved only between hMTH1 and hMYH, which may be involved in 2-OH-A recognition, are shown in a red box.