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Progression-free interval comparison between patients receiving ≤6 previous chemotherapy drugs versus patients receiving ≥7 previous chemotherapy drugs. Cases that received more than six previous chemotherapy drugs had a 3.8 times increased risk of disease progression compared to cases receiving 1–6 previous chemotherapy drugs (P = 0.009). The median PFI for cases receiving 1–6 previous drugs was 46.5 days versus 27 days if they received more than six drugs
