Table 1.
Pharmacokinetic parameters estimated to simulate population pharmacokinetic modelling of the data from the present study (n = 6 cats, buccal administration) and data from the study by Hedges et al (n = 6 cats, intravenous and buccal administration) 26
| Parameter | Estimate | Inter-individual variability (%) |
|---|---|---|
| Buprenorphine bioavailability OTM in gingivostomatitis cats (present study) | 19.5% | 65.7 |
| Buprenorphine bioavailability OTM in normal cats (Hedges et al 26 ) | 28.8% | 19.6 |
| Clearance (l/kg/h) | 1.26 | 1.1 |
| Volume of distribution central compartment (l/kg) | 0.65 | 0.9 |
| Inter-compartmental clearance (l/kg/h) | 1.19 | 2.3 |
| Volume of distribution peripheral compartment (l/kg) | 6.96 | 7.8 |
| Absorption rate constant OTM gingivostomatitis cats (l/h) | 0.573 | NE |
| Absorption half-life OTM gingivostomatitis cats (h) | 1.2 | |
| Absorption rate constant OTM normal cats (l/h) | 1.387 | NE |
| Absorption half-life OTM normal cats (h) | 0.49 |
OTM = buccal administration; NE = could not be estimated for individual