COR	LOE	RECOMMENDATIONS
1	B-NR	1. In patients with AF receiving dabigatran who develop life-threatening bleeding, treatment with idarucizumab is recommended to rapidly reverse dabigatran’s anticoagulation effect.1-3
2a	C-LD	2. In patients with AF receiving dabigatran who develop life-threatening bleeding, treatment with activated prothrombin complex concentrate (PCC) is reasonable to reverse dabigatran’s anticoagulation effect if idarucizumab is unavailable.4,5
1	B-NR* C-LD†	3. In patients with AF receiving factor Xa inhibitors who develop life-threatening bleeding, treatment with either andexanet alfa (apixaban or rivaroxaban,* edoxaban†) or 4-factor prothrombin complex concentratet is recommended to rapidly reverse factor Xa inhibitor’s anticoagulation effect.6,7
1	A	4. In patients with AF receiving warfarin who develop life-threatening bleeding, treatment with 4-factor prothrombin complex concentrate (if available) in addition to intravenous vitamin K is recommended to rapidly achieve INR correction over fresh frozen plasma and intravenous vitamin K treatment.8-10
2b	B-NR	5. In patients with AF who develop major gastrointestinal bleeding, resumption of oral anticoagulation therapy may be reasonable after correction of reversible causes of bleeding and reassessment of its longterm benefits and risks with a multidisciplinary team approach during SDM with patients.11,12

^*B-NR LOE applies to data on apixaban or rivaroxaban.

^†C-LD LOE applies to data on edoxaban.