TABLE 2.

Continuous liver fat (SD) and incident cardiovascular disease, cardiovascular disease-related mortality, all-cause mortality, and incident cancer in the combined cohort

Baseline covariates	Incident CVD HR (95% CI)	CVD-related mortality HR (95% CI)	All-cause mortality HR (95% CI)	Incident cancer HR (95% CI)
Model
Age-sex adjusted	1.21 (1.15–1.28)	1.17 (1.05–1.31)	1.12 (1.06–1.19)	1.01 (0.95–1.08)
Multivariable	1.08 (1.01–1.14)	1.06 (0.94–1.19)	1.09 (1.03–1.15)	1.02 (0.95–1.09)
Multivariable + BMI	1.04 (0.97–1.11)	1.01 (0.89–1.14)	1.06 (1.00–1.12)	0.98 (0.92–1.05)
Time-varying covariates
Model
Age-sex adjusted	1.21 (1.15–1.29)	1.17 (1.04–1.30)	1.11 (1.06–1.18)	1.04 (0.98–1.11)
Multivariable	1.06 (0.98–1.14)	0.99 (0.84–1.17)	1.04 (0.97–1.12)	1.04 (0.91–1.19)
Multivariable + BMI	1.02 (0.95–1.11)	0.96 (0.81–1.14)	1.04 (0.97–1.12)	1.01 (0.90–1.13)

Note: Continuous liver fat is reported as SD of mean liver attenuation. The HR are from fixed effects models. The results for each model are presented for both analyses including baseline covariates and time-varying covariates. Bold values are statistically significant with p<0.05.

Abbreviations: BMI, body mass index; CVD, cardiovascular disease.