Table 1.
Summary of key biochemical investigations through clinical course
| On diagnosis of Acromegaly | Prior to pasireotide | After 3 doses of pasireotide | Reference range | |
|---|---|---|---|---|
| Adrenocorticotropic hormone (ACTH) | 3.6 pmol/L (16.3 pg/mL) | - | < 1.5 pmol/L (< 6.8 pg/mL) | < 12 pmol/L (<54 pg/mL) |
| Cortisol (nmol/L) | 396 nmol/L (14.6 µg/dL) | 452 nmol/L (16.4 µg/dL) | 376 nmol/L (13.6 µg/dL) | 150-520 nmol/L (5.4-18.9 µg/dL) |
| Thyroid stimulating hormone (TSH) | 0.18 mIU/L (0.18 µIU/mL) | 0.78 mIU/L (0.78 µIU/mL) | 2.40 mIU/L (2.40 µIU/mL) | 0.40-4.80 mIU/L (0.40-4.80 µIU/mL) |
| Free thyroxine (FT4) | 10.1 pmol/L (0.78 ng/dL) | 10.5 pmol/L (0.82 ng/dL) | 9.1 pmol/L (0.71 ng/dL) | 8.0-16 pmol/L (0.62-1.24 ng/dL) |
| Growth Hormone (GH) (mIU/L) | 25 mIU/L (8.3 µg/L) | 4.6 mIU/L (1.5 µg/L) | 1.7 mIU/L (0.57 µg/L) | 0-10 mIU/L (0–3.3 µg/L) |
| Insulin-like Growth Factor-1 (IGF-1) | 75.9 nmol/L (580 ng/mL) | 65 nmol/L (497 ng/mL) | 7.0 nmol/L (53 ng/mL) | 7-25 nmol/L (53-191 ng/mL) |
| Prolactin | 800 mIU/L (37.6 µg/dL) | 1353 mIU/L (77.8 µg/dL) | 155 mIU/L (7.3 µg/dL) | 50-300 mIU/L (2.4-14.1 µg/dL) |
| Glucose | 7.8 mmol/L (140 mg/dL) | 5.2 mmol/L (94 mg/dL) | 7.0 mmol/L (126 mg/dL) | 3.6-6.0 mmol/L (65-108 mg/dL) |
| Urea | 5.0 mmol/L (30.0 mg/dL) | 9.2 mmol/L (55.3 mg/dL) | 22.5 mmol/L (135.1 mg/dL) | 4.0-9.0 mmol/L (24.0-54.1 mg/dL) |
| Creatinine | 50 µmol/L (0.57 mg/dL) | 95 µmol/L (1.07 mg/dL) | 425 µmol/L (4.81 mg/dL) | 45-90 µmol/L (0.51-1.02 mg/dL) |
| Estimated glomerular filtration rate (eGFR) | >90 mL/min/1.73m2 | 50 mL/min/1.73m2 | 8 L/min/1.73m2 | >60 mL/min/1.73m2 |