Table 1. Baseline characteristics according to baseline diagnosis.
| n = | Control n = 135 | AD n = 108 | FTD n = 33 | VaD n = 10 | |
|---|---|---|---|---|---|
| Female, n(%) | 286 | 58 (43) | 56 (52) | 13 (39) | 2 (20) |
| Age, in years | 286 | 60 ± 8 | 66 ± 7 | 66 ± 7 | 72 ± 6 |
| APOE e4 carrier, n(%) | 283 | 53 (39) | 74 (69) | 11 (33) | 2 (20) |
| Neuropsychology | |||||
| MMSE | 283 | 28 ± 2 | 22 ± 4 | 24 ± 5 | 24 ± 4 |
| RAVLT learning | 275 | 39 ± 10 | 22 ± 7 | 26 ± 11 | 23 ± 9 |
| RAVLT recall | 275 | 8 ± 3 | 2 ± 2 | 4 ± 3 | 3 ± 3 |
| Animal fluency | 269 | 22 ± 6 | 14 ± 5 | 11 ± 6 | 12 ± 5 |
| TMT-A, in seconds | 273 | 39 ± 22 | 92 ± 84 | 70 ± 55 | 70 ± 24 |
| TMT-B, in seconds | 273 | 100 ± 65 | 294 ± 252 | 204 ± 171 | 219 ± 69 |
| NPI, total score | 211 | 14 ± 16 | 9 ± 9 | 17 ± 15 | 19 ± 21 |
| MRI | |||||
| cMTA score right | 283 | 0.31 ± 0.51 | 1.37 ± 0.94 | 1.54 ± 1.20 | 1.34 ± 1.10 |
| cMTA score left | 283 | 0.31 ± 0.58 | 1.49 ± 1.07 | 1.86 ± 1.48 | 1.99 ± 1.30 |
| cGCA score | 283 | 0.39 ± 0.58 | 1.52 ± 0.86 | 1.89 ± 0.95 | 2.15 ± 0.81 |
| Anterior Posterior index | 283 | -0.25 ± 1.23 | 0.03 ± 1.76 | -1.84 ± 2.79 | -0.44 ± 1.53 |
| AD similarity scale | 283 | 0.47 ± 0.11 | 0.63 ± 0.09 | 0.57 ± 0.10 | 0.61 ± 0.07 |
| WMH volume | 279 | 6.00 ± 5.33 | 9.90 ± 13.1 | 11.08 ± 14.06 | 21.01 ± 18.34 |
| Amyloid-PET | |||||
| Visual Read (neg/pos) | 286 | 107 / 28 | 5 / 103 | 31 / 2 | 6 / 4 |
| Centiloids; mean ± SD | 248 | 11.95 ± 24.31 | 69.40 ± 39.3 | 7.52 ± 21.28 | 15.93 ± 22.87 |
| AUC +, n(%) | 286 | 6 (4) | 81 (75) | 20 (61) | 6 (60) |
AD: Alzheimer’s disease, FTD: Frontotemporal dementia, VAD: Vascular dementia, MMSE: Mini-Mental state Examination, RAVLT: Rey Auditory Verbal Learning Test, TMT: Trail Making Test, NPI: Neuropsychiatric Inventory score, cMTA: computed medial temporal lobe atrophy scale (0–4), derived from volume of hippocampus and volume of inferor lateral ventricle, cGCA: computed global cortical atrophy scale (0–3), derived from concentration of cortical grey matter using voxel based morphometry, AD similarity scale: based on hippocampus ROI, Anterior posterior index: weighted ratio of volumes of the frontal/temporal lobes and parietal/occipital lobes WMH: volume of white matter hyperintensities. MRI volumes are adjusted for head size, AUC +: number of patients fulfilling appropriate use criteria according to [13], operationalized as described in [14].