Table 2. Comparison of different patient groups deriving from the computerized decision support approach using visual reads; matching Fig 1A.
| 1. Direct sufficient certain diagnosis | 2. PET not useful | 3. PET helpful to establish diagnosis | 4. Not diagnosed | |
|---|---|---|---|---|
| n = 155 | n = 71 | n = 33 | n = 27 | |
| Female, n(%) | 68 (44) | 30 (42) | 14 (42) | 17 (63) |
| Age, in years | 62 ± 8 | 64 ± 8 | 67 ± 8 | 66 ± 6 |
| APOE e4 carrier, n(%) | 76 (49) | 33 (46) | 17 (52) | 14 (56) |
| MMSE | 26 ± 4 | 26 ± 3 | 22 ± 5 | 23 ± 4 |
| Amyloid-PET, visual read | ||||
| Negative | 87 (56) | 44 (62) | 12 (36) | 6 (22) |
| Positive | 68 (44) | 27 (38) | 21 (64) | 21 (78) |
| Clinical diagnosis | ||||
| Control | 87 (64) | 41 (30) | 3 (2) | 4 (3) |
| AD | 47 (44) | 20 (19) | 23 (21) | 18 (17) |
| FTD | 17 (52) | 8 (24) | 5 (15) | 3 (9) |
| VaD | 4 (40) | 2 (20) | 2 (20) | 2 (20) |
| Difference with second DSI | 0.33 ± 0.09 | 0.08 ± 0.05 | 0.10 ± 0.06 | 0.11 ± 0.06 |
| AUC +, n(%) | 57 (37) | 24 (34) | 20 (61) | 16 (59) |
MMSE: Mini-Mental state Examination, AD: Alzheimer´s disease, FTD: Frontotemporal dementia, VAD: Vascular dementia, DSI: Disease State Index, Difference with second DSI: DSI based on demographics, APOE, neuropsychology and MRI, AUC +: number of patients fulfilling appropriate use criteria according to [13], operationalized as described in [14]