Table 2.

Overview of circRNAs identified by RNA sequencing and microarrays in GC

Sample	Special treatment	Detection method	Number of circRNAs	Number of circRNA differently expressed(≥ twofold change)	Refs.
3 paired GC and GCN tissues	RNase R	CircRNA microarray	About 2000	100(16 upregulated, 84 downregulated)	[72]
8 paired GC and GCN tissues	RNase R	CircRNA microarray	4458	467(214 upregulated, 253 downregulated)	[71]
3 paired GC and GCN tissues	–	CircRNA microarray	5396	308(107 upregulated, 201 downregulated)	[74]
3 paired III stage GC and GCN tissues	–	CircRNA microarray	–	306(141 upregulated, 165 downregulated)	[73]
3 paired GC and GCN tissues	Ribosome-depleted	RNA-seq	About 3000	180(82 upregulated, 98 downregulated)	[75]
3 groups of gastric tissues(gastric tissue without cancer, GC tissue, GCN tissue)	Ribosome-depleted	RNA-seq	736	–	[76]
5 paired GC and GCN tissues	RNase R	Microarray chip assay	62998	713(191 upregulated, 522 downregulated)	[77]
3 paired plasma of patients and healthy persons	–	CircRNA microarray	5396	343(171 upregulated, 172 downregulated)	[78]
6 paired GC and GCN tissues	–	CircRNA microarray	2070	400(176 upregulated, 264 downregulated)	[79]