Fig. 1.

HBO1 is a MYST lysine acetyltransferase. a HBO1 consists of the N-terminal domain (NTD) and MYST domain. b HBO1 comprises a conserved MYST domain in the C-terminus. Cartoon models indicate the highly conserved MYST domain of protein family members MYST1 (also known as MOF or KAT8) (177–449 a.a, PDB: 5WCI), HBO1 (also known as MYST2, or KAT7) (336–606 a.a, PDB: 5GK9), and MYST3 (also known as MOZ, or KAT6A) (497–780 a.a, PDB: 2OZU). BRPF2 (also called BRD1) binds to HBO1 in a cervical-loop structure proximity to the MYST domain to facilitate histone binding. c NTD of HBO1 consists of a number of loops and a small part of the helix. The structure is highly flexible, which may provide abundant conformation changes for HBO1 activity regulation or protein binding