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. 2019 Sep 18;77(4):637–649. doi: 10.1007/s00018-019-03296-x

Fig. 5.

Fig. 5

Design of targeting molecules and potential strategies for HBO1 inhibition. a MYST domain of HBO1 contains abundant sites for molecule binding. BRPF2-binding site (#1), acetyl-CoA-binding site (#2) and positive charge pocket (#3) provide potential sites for inhibitor binding. b miRNA is another approach for the regulation of HBO1 expression. For example, Hsa-miR-548a-3p is predicted to target on a 7mer-m8 site of 3′ UTR to inhibit HBO1 gene expression