Fig. 1.

mRNA expression of the Wnt family of proteins in the healthy human spinal cord. This figure shows data obtained from the evaluation, by quantitative Real-Time PCR, of the mRNA expression of the different components of the Wnt family of proteins in the healthy human spinal cord (n = 7). As shown, we found detectable mRNA expression of most Wnt ligands (Wnt2, 2b, 3, 4, 5a, 5b, 6, 7a, 7b, 8b, 9b, 10a, 10b, 11, and 16) (a), receptors [Frizzled (Fz)1–10, receptor tyrosine kinase-like orphan receptor (Ror) 1 and 2, protein tyrosine kinase 7 (PTK7) and Ryk] (b), co-receptors [low-density lipoprotein receptor protein (LRP) 5 and 6] (b), and soluble modulators [Dickkopf (Dkk) 1–4, secreted Frizzled-related proteins (sFRP) 1–5 and the Wnt inhibitory factor 1 (Wif1)] (c) in the human spinal cord under physiological conditions. Data are presented as the ratio between each gene of interest and 18s