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Proposed model for TGF-β1-induced myofibroblast differentiation via microtubule acetylation on a soft matrix. Model showing entry of YAP into the nucleus through an acetylated microtubule and dynein complex accompanying the Smad2/3 complex in response to TGF-β1; this is required for myofibroblast differentiation on a soft matrix, which is critical for the progression of fibrotic diseases including liver fibrosis
