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Non-canonical functions of LSD1 beyond its demethylase activity: (1) LSD1 destabilizes FBXW7 by promoting FBXW7 self-ubiquitylation. (2) LSD1 protects ERRα from proteasome-dependent degradation, and ERRα enhances the H3K9 demethylation activity of LSD1. (3) LSD1 destabilizes p62 and inhibits autophagy in gynecologic cancers. (4) LSD1 collaborates with ZNF217 to activate a lethal prostate cancer gene network, thus promoting the cell survival of cancer cells
