Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Maintenance of cellular homeostasis through inducers and scavengers of ROS. ROS can be produced by mitochondria, NADPH oxidases, hypoxia, metabolism, ER stress, cyclooxygenase and oncogenes including HRAS, FLT3-ITD, BCR-ABL, AKT, NF-kB, STAT3 and STAT5. On the other hand, ROS can be eliminated via activation of the dietary antioxidants, glutathione peroxidase, peroxiredoxin, catalase, NRF2, NADPH, SOD and tumor suppressor gnes including BRCA1, BRCA2, TP53, PTEN, FXOP3 and ATM
