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Role of the NRF2/KEAP1 antioxidant pathway for maintaining cellular homeostasis. Under normal physiological condition, NRF2 interact with KEAP1 to activate Cul3‐dependent ubiquitination and its degradation via the proteasome. Under stress or induced condition, NRF2 dissociates from KEAP1 and translocates into the nucleus. NRF2 forms a heterodimer with sMaf protein as well as to ARE to initiate the transcription of several downstream genes
