Table 1.

HECTD3-mediated protein ubiquitination

Substrate	Ub linkage	Molecular function	Cellular function	References
Tara	–	proteasomal degradation	Cell cycle and formation of multipolar spindle	[56]
Syntaxin 8	–	–	Neurodegenerative diseases	[57]
MALT1	Non K48	Increase in MALT1 protein stability	Antiapoptotic chemoresistance	[58]
	K27, K29	Activation of NF-κB signaling	Promotion of the differentiation of Th17 cells	[59]
Caspase-8	K63	Inhibition of caspase-8 activity	Inhibition of extrinsic apoptosis	[60]
Caspase-9	K27, K29	Inhibition of caspase-9 activity	Inhibition of intrinsic apoptosis	[61]
CRAF	–	Proteasomal degradation	Restriction of MAPK pathway	[62]
TRAF3	K63	Activation of TBK1	Promotion of type I interferon production and bacterial infection	[63]
Stat3	K27	Promotion of Stat3 activation	Induction of Th17 cell differentiation	[59]