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Genomic regulatory elements at the Il10 locus in T-helper cells. The murine Il10 gene comprises five exons and many cis-regulatory elements, which are identified as DNase I hypersensitivity sites (DHSs). In Th cells, there are four major functional DHSs: DHS-9, DHS-transcriptional start site (DHS-TSS), DHS + 3, and DHS + 6.5. Different transcription factors bind to those sites to regulate IL-10 expression in different cell types
