Fig. 1.

Neuroprotective effects of sAPPα: Schematic diagram representing how sAPPα, the soluble metabolite of APP, was able to protect the neuronal cells against Aβ and NMDA-induced toxicities, increased the synaptogenesis and neurite outgrowth and was able to restore the impaired memory and thus synaptic plasticity in mice. In addition, sAPPα is able to modulate several cell signaling pathways like PI3K, MAPK, and GSK3β and has shown to inhibit tau hyperphosphorylation and afford neuroprotection in different in vitro models