Fig. 2.

Neurogenic role of sAPPα: Sagittal view of rodent brain showing the two distinct regions of the brain with neurogenic potential. Schematic diagram showing how sAPPα plays a vital role in generation, migration and differentiation of neural stem cells at subgranular zone and subventricular zone along with rostral migratory route. sAPPα acts as a vascular niche signal in the subventricular zone (SVZ) and it has an ability to bind to the surface of neural stem cells and regulate their proliferation and differentiation. It increases the number of neural progenitor cells and GFAP-positive cells and helps in migration and differentiation of the neural stem cells which finally migrate via RMS and differentiate into local circuit interneurons