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Senescence-associated secretory phenotype (SASP) may contribute to age-related macular degeneration (AMD) in several pathways. SASP results in release of cytokines, chemokines, growth factor and other molecules that may change the phenotype of the source cells and neighboring cells. These changes may be in line with pathways of AMD pathogenesis. BRB blood–retina barrier, BrMb Bruch’s membrane
