Fig. 3.

Pancreatic dysplasia in F1 GCK-NFS rabbits. a Histological images of the pancreas in WT and GCK-NFS rabbits. H.E. staining (HE), immunohistochemical staining (in brown color) for insulin (INS) and glucagon (GLA) are shown. Levels of serum insulin (b), serum glucagon (c), serum pancreatic amylase (d) and serum pancrelipase (e) were measured in WT, GCK-HET and GCK-HOM rabbits in F1 generation. Blood glucose and insulin were measured after a 6-h fasting. The data were expressed as the mean ± SEM. A probability of p < 0.05 was considered as statistically significant. *, p < 0.05; **, p < 0.01; ***, p < 0.005. ns, not significant