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. 2019 May 22;76(21):4341–4354. doi: 10.1007/s00018-019-03114-4

Fig. 1.

Fig. 1

HFD significant increases in body weight and liver fat, which returned to normal after diet reversal to NC. a Body weight changes. *P < 0.05 for NC vs. HFD, two-way ANOVA. (n = 13–16 mice per group) b Liver weight changes. *P < 0.05 for NC vs. HFD, #P < 0.05 for HFD vs. R_HFD, one-way ANOVA (n = 13–16 mice per group). c Representative H&E stains show fat content in liver tissue. (Top row) after test diet; (bottom row) after reversal to NC diet. The scale bar is 100 µm. d Quantification of liver fat fraction based on MRI image analysis. *P < 0.05 NC vs. HFD and HFD vs. HFrD, #P < 0.05 HFD vs. R_HFD, one-way ANOVA. (n = 3–5 mice per group). e Total serum cholesterol level. *P < 0.05 NC vs. HFD or HFrD, #P < 0.05 HFD vs. R_HFD, HFrD vs. R_HFrD t test (n = 13–16 mice per group). f Serum triglyceride levels. *P < 0.05 for NC vs. HFD and R_NC vs. R_HFD one-way ANOVA. (n = 9–16 mice per group)