Table 2.
Grades of steatosis and fibrosis in liver tissue by the Brunt scoring
| NC (n = 10) | HFD (n = 13) | HFrD (n = 11) | R_NC (n = 15) | R_HFD (n = 16) | R_HFrD (n = 14) | |
|---|---|---|---|---|---|---|
| Steatosis | ||||||
| Grade 0 | 8 (80%) | 5 (45.45%) | 14 (93.33%) | 12 (75%) | 4 (28.57%) | |
| Grade 1 | 2 (20%) | 8 (61.54%)* | 6 (54.55%) | 1 (6.67%) | 4 (14%) | 10 (71.43%) |
| Grade 2 | ||||||
| Grade 3 | 5 (38.46%)* | |||||
| Micro-vesicular | 12 (92.31%) | 5 (45.45%) | 1 (6.67%) | 4 (25%) | 10 (71.43%) | |
| Macro-vesicular | 9 (69.23%) | 3 (36.36%) | 1 (6.25%) | |||
| Fibrosis | ||||||
| Grade 0 | 10(100%) | 8 (61.54%) | 8 (72.73%) | 14 (93.33%) | 15 (93.75%) | 14 (100%) |
| Grade 1 | 5 (38.46%) | 3 (27.27%) | 1 (6.67%) | 1 (6.25%) | ||
Steatosis: grade 0: < 5% hepatocytes involved, grade 1: 5–33% hepatocytes involved, grade 2: 33–66% hepatocytes involved, grade 3: > 66% hepatocytes involved
Fibrosis: grade 0: no fibrosis, grade 1: zone3 perivenular, perisinusoidal, or pericellular fibrosis; focal and extensive
*P significant NC vs HFD, one way ANOVA in steatosis < 0.05