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. 2018 Oct 16;76(1):67–87. doi: 10.1007/s00018-018-2925-6

Fig. 2.

Fig. 2

Identifying unique subpathways in the study groups. Construction and conversion of human pathway maps to a gene–gene network based on association rules (Step I); the incorporation of omics data onto gene–gene networks in the form of weights in their edges (Step II); and design and implementation of the subnetwork identification method based on an agglomerative technique starting from seed genes of interest (GoI) (Step III)