Fig. 1.

HBP1 structure, posttranslational modifications and interactions. The HBP1 protein comprises three major domains: a transcriptional activation domain (in green), a transcriptional repression domain (in red), and an HMG-box DNA-binding domain (in blue). The activation and repression domains of HBP1 were defined by Lavender et al. [3] and Sampson et al. [26], respectively. Posttranslational modification sites of HBP1 are indicated below the HBP1 structure: Ac, acetylation (in orange); P, phosphorylation (in blue by PIM-1, in green by p38, in Bordeaux by AKT); Ub, ubiquitination (in gray). Proteins that directly interact with HBP1 are represented above HBP1 at their described binding site. See text for details