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Neural crest specification and delamination. Neuroectodermal patterning is a very dynamic developmental program in which Notch signaling and secreted ligands such as BMP, WNT and FGF will specify the posterior neural border and the neural crest arising at the neural folds upon closure of the neural tube. During different stages, different genes are expressed that mark the neural plate border and premigratory and dispersed neural crest cells
