Fig. 3.

ODN suppresses astrogliosis in MPTP-treated mice. A Representative images of GFAP immunostaining in the substantia nigra pars compacta (SNpc) 7 days after treatment with NaCl (Sham; A-a), MPTP (3 × 20 mg/kg; A-b), ODN (10 ng/10 µl; A-c) and MPTP + ODN (A-d). Scale bar = 100 µm. SNpc (substantia nigra pars compacta), SNr (substantia nigra pars reticulate), VTA (ventral tegmental area) B Relative GFAP immunofluorescence intensity in the SNpc 7 days after sham, MPTP, ODN, and MPTP + ODN treatment. All values are expressed as mean ± SEM from five animals and statistical analysis was conducted by ANOVA followed by Bonferroni’s test. ***P < 0.001 vs saline-treated mice; ^### P < 0.001 vs MPTP-treated mice