Fig. 5.

ODN suppresses stimulation of caspase-3 activity in MPTP-treated mice. Caspase-3 (Casp-3) activity was determined in the substantia nigra pars compacta (SNpc) (a) and striatum (b) 7 days after treatment with NaCl (Sham), MPTP (3 × 20 mg/kg), ODN (10 ng/10 µl) and MPTP + ODN. Each value, expressed as a percentage of control, represents the mean (±SEM) obtained from 10 animals and statistical analysis was conducted by ANOVA followed by Bonferroni’s test. *P < 0.05, ***P < 0.001, NS, Ns, not statistically different vs saline-treated mice; ^# P < 0.05; ^### P < 0.01 vs MPTP-treated mice