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. 2018 Feb 7;75(10):1803–1826. doi: 10.1007/s00018-018-2759-2

Table 1.

Small-molecule compounds targeting autophagy-related proteins or autophagic process in cancer therapy

Compound Target Structure Cell type Reference
Rapamycin mTORC1 graphic file with name 18_2018_2759_Figa_HTML.gif HEI193,08031-9,ESC-FC1801 [108, 153]
Temsirolimus mTORC1 graphic file with name 18_2018_2759_Figb_HTML.gif MDA-MB-468, MDA-MB-435, MDA-MB-231, MCF-7, T-47D, SKBR-3, BT-474 [108, 109, 154]
Everolimus mTORC1 graphic file with name 18_2018_2759_Figc_HTML.gif HEY, SKOV3, OVCAR5, IGROV1, OV433 [108, 155]
Ridaforolimus mTORC1 graphic file with name 18_2018_2759_Figd_HTML.gif MCF-7 [156]
PI103 mTOR/PI3K graphic file with name 18_2018_2759_Fige_HTML.gif PC-3, DU145, LNCaP [108, 157]
PI540 mTOR/PI3K graphic file with name 18_2018_2759_Figf_HTML.gif – [112, 157]
PI620 mTOR/PI3K graphic file with name 18_2018_2759_Figg_HTML.gif – [112, 157]
NVPBEZ235 mTOR/PI3K graphic file with name 18_2018_2759_Figh_HTML.gif NCI-N87, SNU216, MCF-7, BT47, [158, 159]
GSK2126458 mTOR/PI3K graphic file with name 18_2018_2759_Figi_HTML.gif CNE-1, CNE-2, 5-8F, 6-10B [108, 160]
BGT226 mTOR/PI3K graphic file with name 18_2018_2759_Figj_HTML.gif Hep3B, HepG2, SNU449, SNU475 [108, 161]
XL765 mTOR/PI3K graphic file with name 18_2018_2759_Figk_HTML.gif CLL [108, 162]
GDC0980 mTOR/PI3K graphic file with name 18_2018_2759_Figl_HTML.gif LNCaP, Vcap, 22Rv1 [108, 163]
SF1126 mTOR/PI3K graphic file with name 18_2018_2759_Figm_HTML.gif Hep3B, HepG2, SK-Hep1, Huh7 [108, 164]
PP242 mTOR graphic file with name 18_2018_2759_Fign_HTML.gif OVCAR-3 [114, 165]
AZD8055 mTOR graphic file with name 18_2018_2759_Figo_HTML.gif L3.6pl, MV4-11 [117, 166, 167]
AZD2014 mTOR graphic file with name 18_2018_2759_Figp_HTML.gif MCF7, SCC4, SCC25, HCCLM3, Huh-7, SMMC-7721, HepG2, HL-7702 [117, 168–170]
OSI027 mTOR graphic file with name 18_2018_2759_Figq_HTML.gif Panc-1, BxPC-3, CFPAC-1 [118, 171]
INK128 mTOR graphic file with name 18_2018_2759_Figr_HTML.gif CHLA-255, SK-N-AS, SH-SY5Y, IMR32, LA–N-6, CHLA-255, Miapaca-2, Panc1, PSN1, MRC9, RAW264.7,MCF7, SUP-B15,MCC-2, MCC-3, MCC-5 [115, 116, 172–177]
Palomid 529 mTOR graphic file with name 18_2018_2759_Figs_HTML.gif CWR22R-2152, CWR22R-2272, CWR22R-2274, LnCaP-104S, LnCaP-104R1, C4-2B, DU145, PC3, VCaP, DuCaP [119, 126]
LYN-1604 ULK1 graphic file with name 18_2018_2759_Figt_HTML.gif MDA-MB-231 [123, 124]
SBI-0206965 ULK1 graphic file with name 18_2018_2759_Figu_HTML.gif A549 [125]
Compound 6 ULK1 graphic file with name 18_2018_2759_Figv_HTML.gif – [126]
MRT67307 ULK1 graphic file with name 18_2018_2759_Figw_HTML.gif – [127]
MRT68921 ULK1 graphic file with name 18_2018_2759_Figx_HTML.gif – [127]
SAR405 Vps34 graphic file with name 18_2018_2759_Figy_HTML.gif HeLa, H1299 [130]
PI3KD/V-IN-01 Vps34 graphic file with name 18_2018_2759_Figz_HTML.gif AML, CLL [134]
VPS34-IN1 Vps34 graphic file with name 18_2018_2759_Figaa_HTML.gif U2OS [131]
PIK-III Vps34 graphic file with name 18_2018_2759_Figab_HTML.gif H4, HeLa, PSN-1, Panc10.05, RKO [132]
Flubendazole Atg4 graphic file with name 18_2018_2759_Figac_HTML.gif MDA-MB-231 [135, 136]
NSC185058 Atg4 graphic file with name 18_2018_2759_Figad_HTML.gif 293T, HuH7, Saos-2 [137]
Chloroquine Lysosome graphic file with name 18_2018_2759_Figae_HTML.gif Hs578t, MDA-MB-231, SUM159, SW1116, HCT116, HT-29, SW480, NCM460, RT4, T24, PC3, SV-Huc-1 [140–142]
Hydroxychloroquine Lysosome graphic file with name 18_2018_2759_Figaf_HTML.gif MCF-7, HDFs, RT4, 5637, T24, PC3, SV-Huc-1 [142, 143]
Au(I)-loaded NPs Lysosome graphic file with name 18_2018_2759_Figag_HTML.gif MCF-7 [144]
VATG-027 Lysosome graphic file with name 18_2018_2759_Figah_HTML.gif U2OS [145]
VATG-032 Lysosome graphic file with name 18_2018_2759_Figai_HTML.gif U2OS [145]
Lys05 Lysosome graphic file with name 18_2018_2759_Figaj_HTML.gif HT29 [146]
Matrine Lysosome graphic file with name 18_2018_2759_Figak_HTML.gif SGC7901 [147]