Fig. 3.

Inhibition of NLRP3 inflammasome decreased the population of regular T cells in a HNSCC mouse model. a Flow cytometry shows the population variation of CD4⁺CD25⁺Foxp3⁺ Tregs in the spleen of PBS- and MCC950-treated mice. b Quantification and statistical analysis of regular T cell ratio in CD4⁺ cells among three groups (data shown as mean ± SEM). c Representative immunohistochemical staining images show the density difference of Foxp3-positive cells in Tgfbr1/Pten2cKO mice tumors of three groups; scale bar = 50 μm; the arrow points to positive staining. d Quantification of IHC histoscore of Foxp3 (data shown as mean ± SEM)