Fig. 1.

Genetic interactions that can contribute to a synthetic lethal relationship. The concurrent inactivation of two factors in the genetic relationship can result in cumulative functional inactivation or cell death. a BRG1 and BRM are mutually exclusive subunits of a complex. b ATR and ATM act synergistically to sense DNA damage, an important process that maintains genomic stability in the cell. c The repressor protein BAG1 inhibits an anti-proliferative apoptotic mechanism that counteracts proliferation induced by the Myc oncoprotein