Fig. 5.

Enhanced expression of GADD45α affects fatty acid beta-oxidation-, tricarboxylic acid cycle- and glycogenolysis-related gene expression after APAP treatment. a–c The mRNA levels of genes involved in fatty acid beta-oxidation, tricarboxylic acid cycle and glycogenolysis in AML-12 cells with the enhanced expression of GADD45α after APAP treatment for 6 h. d–h The mRNA levels of genes involved in fatty acid beta-oxidation, tricarboxylic acid cycle and glycogenolysis in primary mouse hepatocytes with overexpression of GADD45α after APAP treatment for 6 h. The relative mRNA levels were normalized to 36B4 and subsequently normalized to the control group. Data are expressed as the mean ± standard error of the mean, *P < 0.05, **P < 0.01