Table 1.
Maternal proteins targeted for degradation in different organisms
| Substrate | E3 ligase | Function | References | |
|---|---|---|---|---|
| Mouse | Cyclin B | APC/C | Meiosis I and II | [99] |
| Cyclin B1 | RFPL4 | Meiosis I and II | [100] | |
| Emi2 | SCFβ-TrCP | Metaphase II exiting | [205] | |
| TAB1 | RNF114 | NF-κB pathway activation | [122] | |
| MATER | UCHL1 | Polyspermy block | [132] | |
| Xenopus | CyclinA, Cyclin B | APC/C(CORT) | Meiosis I and II | [102] |
| Mtrm | APC/C(CORT) | Polo kinase activation | [105] | |
| Cort | APC/C | Embryonic mitosis | [102] | |
| CPEB1 | SCFβ-TrCP | Maternal mRNAs polyadenylation | [129] | |
| C. elegans | MEI-1/katanin | CUL-3MEL-26 | Meiotic spindle degradation | [109] |
| EGG-3 | APC/C | MBK-2 activation | [117] | |
| OMA-1/2 | CRL1LIN-23, CRL1FBXB-3, CRL2ZYG-11 | ZGA | [175] |