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. 2018 Nov 3;76(3):539–559. doi: 10.1007/s00018-018-2958-x

Table 1.

putative miRNA-493 target genes clustered by the IPA analysis or by miRNA correlation to potential targets on mRNA and protein level of the TCGA ovarian serous cystadenocarcinoma dataset

Potential target Gene name Cluster function Correlation coefficient p value
STAT3 Signal transducer and activator of transcription 3 IPA analysis: ovarian CA signalling
HMGA2 High mobility group AT-Hook 2 IPA analysis: ovarian CA signalling
MAP2K5 Mitogen-activated protein kinase kinase 5 IPA analysis: ovarian CA signalling
AKT2 AKT serine/threonine kinase 2 IPA analysis: ovarian CA signalling
PEA15 Phosphoprotein enriched in astrocytes 15 TCGA analysis, correlation to mRNA expression − 0.16034 0.00198
ALKBH3 AlkB Homolog 3, alpha-ketoglutaratedependent dioxygenase TCGA analysis, correlation to mRNA expression − 0.14968 0.00391
FMR1P Fragile X mental retardation 1 TCGA analysis, correlation to mRNA expression − 0.12411 0.01692
PIK3R3 Phosphoinositide-3-kinase regulatory subunit 3 TCGA analysis, correlation to mRNA expression − 0.10594 0.04168
STK38L Serine/threonine kinase 38 like TCGA analysis, correlation to mRNA expression − 0.09455 0.06929
EEF2 K Eukaryotic elongation factor 2 kinase TCGA analysis, correlation to protein expression − 0.25752 0.00003
FOXM1 Forkhead box M1 TCGA analysis, correlation to protein expression -0.18188 0.00350
JAK2 Janus kinase 2 TCGA analysis, correlation to protein expression − 0.17445 0.00512
ADAR1 Adenosine deaminase, RNA specific TCGA analysis, correlation to protein expression − 0.17357 0.00536
GAB2 GRB2 associated binding protein 2 TCGA analysis, correlation to protein expression − 0.16114 0.00981
RAF1 Raf-1 proto-oncogene, serine/threonine kinase TCGA analysis, correlation to protein expression − 0.16050 0.01011
MAPK1 Mitogen-activated protein kinase 1 TCGA analysis, correlation to protein expression − 0.13321 0.03314