Fig. 3.

Regulation of lipid metabolism by lncRNAs. a HULC modulates lipid metabolism by miR-9/PPARA/ACSL1 pathway in hepatoma cells. b SNHG16, which is activated by the Wnt pathway/c-Myc axis in colorectal cancer, promotes the expression of genes involved in fatty acid biosynthesis, such as SCD. c LNMICC, a target of miR-190, induces binding of NPM1 to the promoter of FABP5 and activates its expression in cervical cancer. Consequently, FABP5 regulates the reprogramming of fatty acid metabolism. Please see more detail in the text. HULC highly upregulated in liver cancer, PPARA peroxisome proliferator activated receptor alpha, ACSL1 acyl-CoA synthetase long chain family member 1, SNHG16 snoRNA host gene 16, SCD stearoyl-CoA desaturase, LNMICC lncRNA associated with lymph node metastasis in cervical cancer, NPM1 nucleophosmin 1, FABP5 fatty acid binding protein 5