Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Functions of MDSCs in the generation of immunosuppression in inflamed tissues. Chemokines secreted by inflamed tissue recruit MDSCs into the tissue where MDSCs generate an anti-inflammatory microenvironment by activating Tregs and Bregs and producing immunosuppressive mediators. MDSCs suppress the functions of effector T cells as well as inhibit B cells and dendritic cells and thus reduce antibody production
