Fig. 9.

D2A promotes cell proliferation via the activation of EGFR. In cells constitutively expressing uPAR on the cell surface, the association of domain 3 of uPAR with the integrin stabilizes the uPAR–integrin complex. D2A binding to αvβ3 integrin of pre-formed uPAR–integrin complex initiates the formation of uPAR-αvβ3 integrin–EGFR complex leading to the dimerization and phosphorylation of EGFR, activation of ERKs and stimulation of cell proliferation