Fig. 2.

Polycomb repressive complex 2-mediated transcriptional repression. The polycomb repressive complex 2 (PRC2) is made of the core components enhancer of zeste homolog 2 (EZH2), embryonic ectoderm development (EED), and suppressor of zeste 12 (SUZ12). These associate with other subunits, such as RBAP46 (also termed RBBP7), RBAP48 (RBBP4), Jumonji and AT-rich interaction domain containing 2 (JARID2; not shown), AE binding protein 2 (AEBP2; not shown) and polycomb-like proteins (PCL; not shown). The PRC2 complex binds to unmethylated cytosin-guanine dinucleotide (CpG) islands and, via tri-methylation of lysine 27 in histone 3 (H3K27m3) of adjacent nucleosomes, mediates silencing of repressed genes