Table 2.

Molecular phenotypes associated with TUSC3 in different types of cancer

Cancer	Expression change OF TUSC3	TUSC3-associated molecular phenotype	Integrated role	References
Ovary	Downregulation by promoter hypermethylation	UPR EMT	TSG	[10, 38, 61]
PROSTATE	Downregulation	UPR N-Glycosylation Akt	TSG	[9]
Glioblastoma multiforme	Downregulation by promoter hypermethylation	Akt	TSG	[35, 63]
Breast cancer	Downregulation by miRNA	(1) SOX2 (2) miR-181a-5p (2) miR-30e-5p	TSG	[72, 73]
Pancreatic cancer	Homozygous deletion	NF-κB	TSG	[48, 62]
Oral squamous cell carcinoma	Homozygous deletion	N/A	TSG	[74]
Hepatocellular carcinoma	Loss of heterozygosity	N/A	N/A	[46]
Small cell lung cancer	Downregulation	N/A	TSG	[75]
Larynx and pharynx carcinoma	Loss	N/A	TSG	[76]
Esophageal squamous cell carcinoma	Downregulation	N/A	TSG	[77]
Non-small-cell lung cancer	Downregulation by promoter hypermethylation	Wnt/β-catenin	TSG	[78]
	Upregulation	Hedgehog	Oncogene	[64]
Colorectal cancer	Upregulation	MAPK PI3K/Akt Wnt/β-catenin	Oncogene	[60]
Head and neck squamous carcinoma	Upregulation by amplification	N/A	Oncogene	[59]
Thyroid cancer	Upregulation (gain)	N/A	Oncogene	[57, 59]

N/A not applicable (data unavailable)