Fig. 7.

Location of pore-lining TM8 side-chains in the CFTR structure. a, b Relative locations of TM8 residues Y913 (orange), Y914 (yellow), and Y917 (red) compared with L102 (TM1; blue) and F337 (TM6; green). These side-chains only are shown as space-filling models within the overall structures of the membrane-spanning parts of human CFTR in the phosphorylated, ATP-bound state (a) and the dephosphorylated, ATP-free state (b) (see also Fig. 1). c A more detailed view of side-chains from different TMs proposed to play a role in the function of the narrow pore region, viz., L102 (TM1), F337, T338, S341 (TM6), Y913, Y914, Y917 (TM8—present study), S1118 (TM11), and T1134 (TM12). These side-chains only are shown as sticks within a cross section of the pore in the phosphorylated, ATP-bound state (as in a)