Table 1.

Selected list of HSF1 target genes identified so far

Target gene	Organism/cell culture	Function	Regulation	References
ERO1	Yeast	Unfolded protein response	Up	[47]
SIS1	Yeast	Oxidative stress response	Up	[51]
CUP1	Yeast	Oxidative stress response	Up	[51]
BTN2	Yeast	Oxidative stress response	Up	[51]
SGT2	Yeast	Oxidative stress response	Up	[51]
SSA3	Yeast	Oxidative stress response	Up	[51]
BAG3	HeLa	Chaperones	Up	[116]
	HeLa	Chaperones	Up	[117]
Fas	A549 cells	Apoptosis	Up	[123]
Tdag51	Mice	Apoptosis	Up	[121]
p21	U2OS cells	Apoptosis	Up	[127]
gadd45	U2OS cells	Apoptosis	Up	[127]
miR-34a	Mice, Sca-1+ cells	Apoptosis	Down	[118]
p62	RKO, A549 and MCF-7 cells	Autophagy	Up	[55]
	C57BL/6J mice, HeLa and HEK293 cells	Autophagy	Up	[56]
ATG10	Tomato	Autophagy	Up	[67]
ATG18f	Tomato	Autophagy	Up	[67]
Atg7	MDA-MB-231 and -436 cells	Autophagy	Up	[65]
lgg-1	C. elegans	Autophagy	Down	[38]
lgg-2	C. elegans	Autophagy	Down	[38]
epg-9	C. elegans	Autophagy	Down	[38]
UBB	HepG2	Ubiquitin–proteasome system	Up	[77]
UBC	HepG2	Ubiquitin–proteasome system	Up	[77]
let-70	C. elegans	Ubiquitin–proteasome system	Up	[79]
ubi-1	C. elegans	Ubiquitin–proteasome system	Up	[79]
rpn-3	C. elegans	Ubiquitin–proteasome system	Up	[79]
cyp-35B1	C. elegans	Ageing	Up	[166]
sip-1	C. elegans	Ageing	Up	[166]
daf-7	C. elegans	Ageing, development	Down	[17]
daf-9	C. elegans	Ageing, development	Up	[17]
maoc-1	C. elegans	Dauer development	Up	[150]
daf-22	C. elegans	Dauer development	Up	[150]
ABCB1/MDR	Mouse melanoma B16F10 cells	Multidrug resistance	Up	[83]
	HeLa cells	Multidrug resistance	Up	[81]
	U2-OS cells, HepG2	Multidrug resistance	Up	[82]
Sat III	HeLa cells	Pericentric long non-coding RNA Nuclear stress bodies	Up	[100–102]
TERRA	HeLa cells	Subtelomeric long non-coding RNA Long non-coding RNA	Up	[116]
FUT4	Human breast cancer cells (MCF-7, MDA-MB-231)	Cell growth, cell cycle	Up	[140]
IER5	HeLa cells	Cell growth, cell cycle	Up	[141]
JUN	HeLa cells	Cell growth, cell cycle	Up	[136]
FoxM1	Mouse embryonic fibroblast cells	Cell growth, cell cycle	Up	[139]
HuR	Mouse cell culture, MCF7, MCF10A, SKBR-3, MDA-MB-231, SK-OV-3	Hypoxia	Up	[142]
FOS1	Human and rodent cells	Cell growth, cell cycle	Up	[133]
	Human and rodent cells	Cell growth, cell cycle	Up	[134]
G-CSF	Mice	Immunity	Down	[175]
IL-6	Mouse embryo fibroblast (MEF) cells	Immunity	Chromatin opening	[85]
	Mouse embryo fibroblast (MEF) cells	Immunity	Chromatin opening	[59]
	Mice spleen cells	Immunity	Up	[87]
TNFα	Mice	Immunity	Down	[174]
	Human peripheral blood monocytes	Immunity	Down	[177]
	Mice, murine macrophages	Immunity	Down	[173]
CXC chemokine genes (CXCL-1, -2, -5, -8)	Human pulmonary epithelial-like A549 cells	Immunity	Up, down	[178]
c-fms	Chinese hamster ovaricytes	Immunity	Down	[176]
IL-1beta	Chinese hamster ovaricytes	Immunity	Down	[176]
	Human monocyte cell line THP-1	Immunity	Up	[191]
LIF1	Mice	Immunity	Down	[191]
HLA-G	Human melanoma cell line M8 (HLA-A1, -A2, -B12, and B40/male)	Immunity	Up	[172]
ATF3	MEFs	Immunity	Up	[59]
SPI1/PU.1	Mice and monocyte	Immunity	Up	[182]
COX-2	Primary human umbilical vein endothelial cells	Immunity	Up	[179]
tkt-1	C. elegans	Metabolism	Up	[38]
aldo-2	C. elegans	Metabolism	Up	[38]
R05F9.6	C. elegans	Metabolism	Up	[38]
CKS2	human breast cancer cell line	Cancer, cell cycle	Up	[150]
LY6K	Human breast cancer cell line	Cancer, signalling	Up	[150]
RBM23	Human breast cancer cell line	Cancer, gene regulation	Up	[150]
CCT6A	Human breast cancer cell line	Cancer, protein folding	Down	[150]
CKS1B	Human breast cancer cell line	Cancer, cell cycle	Up	[150]
ST13	Human breast cancer cell line	Cancer, protein folding	Down	[150]
EIF4A2	Human breast cancer cell line	Cancer, translation	Up	[150]

Non-HSP-related targets involved in cellular stress response are shown only. For a comprehensive list of HSF1 target genes, see Table S1