Fig. 2.

Adamts17-/- mice recapitulate Weill-Marcehsani syndrome. a Distal forepaws and hindpaws of WT and Adamts17-/- (KO) mice at 8 months of age. Scale bars, 5 mm. b Bone length of forepaws and hindpaws of 8-month-old male WT (n = 7) and KO (n = 5) mice. *P < 0.05 versus WT. c Gross inspection of skin stiffness of 3- and 8-month-old WT and KO mice. Mice were anesthetized, shaved, and suspended by forceps. d Hematoxylin and eosin (H&E) and Masson’s trichrome staining of skin from 3- and 8-month-old WT and KO mice. Scale bars, 300 µm. Statistical significance was calculated using a two-tailed unpaired Student’s t test