Fig. 7.

A scheme showing interdependence of lamin A/C, lamin B1 and TPR organization and NPC distribution in HeLa cells. a In control cells, lamin A/C and lamin B1 are fully polymerized, TPR forms nuclear baskets of NPCs that are homogenously distributed at the nuclear envelope. b Long-term TPR depletion results in lamin B1 (but not lamin A/C) network fragmentation, reduction of lamin B1 levels and the presence of NPC-free zones. c Co-depletion of TPR and lamin A restores both lamin B1 network organization and NPC homogenous distribution