Fig. 1.

Influence of selected T-box family members (TBX2, TBX5 and TBX21) on ADAM10- and BACE-1-promoter activity. a–c Data were obtained from a screening approach of 704 human TFs described previously [32]. Bars display mean ± SD from three independent experiments (ns p > 0.05, ***p < 0.001, Unpaired Student’s t test). d EST profile analysis of selected human T-box family members. Indicated TFs were ranked according to relative expression level in the brain as compared to other tissue and in adult compared to other developmental stages using NCBI database information. Values represent transcripts per million (Gene EST/Total EST in pool). Respective values for total brain and adult are marked grey